Pkd1l1 and Pkd2 physically interact and establish left-right asymmetry

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

In mammals, left-right (L-R) asymmetry is established by posteriorly oriented cilia driving a leftwards laminar flow in the embryonic node, thereby activating asymmetric gene expression. The two-cilia hypothesis argues that immotile cilia detect and respond to this flow through a Pkd2-mediated mechanism; a putative sensory partner protein has, however, remained unidentified. We have identified ...

Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis.

The internal organs of vertebrates show distinctive left-right asymmetry. Leftward extracellular fluid flow at the node (nodal flow), which is generated by the rotational movement of node cilia, is essential for left-right patterning in the mouse and other vertebrates. However, the identity of the pathways by which nodal flow is interpreted remains controversial as the molecular sensors of this...

bb̄ Decay Asymmetry and Left - Right Models

It has been pointed out recently by Chanowitz that the Z → b ¯ b decay asymmetry poses a problem for the standard model whether it is genuine or not [1]. If this conflict is interpreted as new physics in the b-quark couplings, it suggests a rather large right handed coupling of the b-quark to the Z-boson. We show that it is possible to accommodate this result in left-right models that single ou...

Twinning and embryonic left-right asymmetry.

Left-right asymmetry in development and disease

Organisms often adopt consistent left-right (LR) asymmetric positioning and morphology of internal organs, a phenomenon known as handedness or chirality. Th e chirality of biomolecules such as sugar and DNA has been recognized for a long time, but the origins of LR asymmetry in living organisms are not yet well understood. In general, the LR patterning is considered to follow four steps: (i) LR...